ABSTRACT
PURPOSE--To study the relation between the average level and variability of blood pressure (VBP) obtained by ambulatory monitoring (AMBP) and the geometric pattern (GP) of the left ventricle (LV) obtained by echocardiography (ECHO) in patients with hypertension (Hy) METHODS--AMBP and ECHO were performed in 37 patients with Hy, divided into three groups: group A--11 women using antihypertensive therapy (AH); group B--15 men using AH and group C--7 male and 4 female without AH. The GP of LV was obtained by ECHO based on mass index (MI) and relative thickness of the wall (RTW). Mean systolic (MSBP) and diastolic (MDBP) were analyzed during daytime (DT) and nighttime (NT) periods. VBP was defined by mean standard deviation (SD) of mean pressures considered. RESULTS--In G-A, there was a significant association between the MI and both VBP and MSBP (r = 0.65 and p < 0.005, r = 0.61, and p < 0.005, respectively), and MSBP and VBP during the DP (r = 0.64 and p < 0.005, r = 0.75, and p < 0.005). In G-B, there was a relation between the LVRTW (r = 0.55 and p < 0.005), and MSBP during the DP (r = 0.65 and p < 0.005). In G-C, there was a significant association (p < 0.005) between the MI and the MDBP in the DP and with the MSBP in the NP (r valueS ranged from 0.51 to 0.66). There was also a significant relation (p < 0.005) between the LVRTW and the SD of all variables in both DP and NP (r ranged from 0.47 to 0.78 and mean diastolic in the wakeful period (r = 0.42 to 0.78) and MDBP in the DP (r = 0.42 and p < 0.05). CONCLUSION--Both the increase in VBP and the mean BP are involved in the changes of LVGP in Hy.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Middle Aged , Hypertension/physiopathology , Arterial Pressure/physiology , Circadian Rhythm , Echocardiography, Doppler, Color , Ventricular Function, Left/physiology , Blood Pressure Monitoring, Ambulatory , Heart Ventricles/pathologyABSTRACT
Objetivo: Estudar critérios diagnósticos para monitorizaçäo ambulatorial da pressäo arterial (MAPA) em grupo de indivíduos normais, selecionados segundo critério detalhado, e levando-se em conta seus próprios limites. Métodos: Foram estudados 40 indivíduos: 30 homens e 10 mulheres. A idade média foi 28 mais ou menos 6 anos. Os critérios de inclusäo foram: pressäo arterial(PA) em repouso menor do que 140/90 MMHg (sistólico/diastólica); ecocardiograma normal; resposta cardiovascular fisiológica durante teste de esforço (TE) máximo em esteira rolante. Foi utilizado para MAPA o Pressurômetro IV da Del Mar Avionics, modelo 1990. Resultados: Para o critério diagnóstico de carga pressórica durante o dia, 38 por cento das medidas sistólicas e l6 por cento das medidas diastólicas ficaram elevadas. Durante a noite 13 por cento das medidas sistólicas e, 13por cento das medidas diastólicas ficaram elevadas. Em relaçäo à cifra diastólica de 90 mmHg, 11 por cento das medidas foram superiores. Comparadas ao nível ideal diastólico, isto é, estatura em centímetros dividida por 2 (estatura-cm/2), 17por cento foram superiores, e em relaçäo à PA máxima no TE, 24 por cento das tomadas ficaram acima. Conclusäo: Na avaliaçäo da normotensäo de um determinado indivíduo seria relevante considerar näo somente o padräo obtido em grupos normais, bem como os desvios observados em relaçäo a seus próprios limites (PA ideal para o indivíduo e PA máxima em esforço)
Subject(s)
Humans , Male , Female , Adolescent , Adult , Arterial Pressure , Blood Pressure Determination , Hypertension/diagnosis , Blood Pressure MonitorsABSTRACT
PURPOSE--To evaluate clinical efficacy and tolerability of isradipine SRO (I.SRO), 5 mg O.D. in essential hypertensives. METHODS--Eighty-three of 87 selected outpatients with a mean age of 51.3 years (ranging from 25 to 65), 33 male, 48 white, 29 black and others of different races, who had clinical supine and orthostatic diastolic blood pressure (DBP) > or = 95 mmHg and < or = 115 mmHg underwent the study. After a three-week wash-out period, patients received I.SRO 5 mg O.D. at 8:00 am for a six-week period (phase I). After this phase, patients received I.SRO 5 mg O.D. at 8:00 pm for a six-week period (phase II). The patients had a follow-up with an interval of three weeks and the ambulatorial blood pressure monitoring (ABPM) for 24 hours was performed with a SpaceLabs 90207 or Del Mar Avionics devices after the wash-out period and at the end of phases I and II. Measurements were performed at 15-min intervals during the day (6 am to 10 pm) and at 30-min intervals during the night (10 pm to 6 am). RESULTS--a) Heart rate did not show significant changes during the treatment period (phases I and II) when compared with the wash-out period; b) causal blood pressure: at the end of both treatment periods (phases I and II) there were statistically significant decreases (p < 0.001) in supine SBP and DBP compared with wash-out values. The mean SBP decreased from 161.6 +/- 14 to 144.3 +/- 13 mmHg (phase I) and to 141.8 +/- 13 mmHg (phase II). The mean DBP decreased from 103.4 +/- 6 to 91.2 +/- 7 (phase I) and to 89.1 +/- 8 (phase II); c) ABPM: the mean systolic 24-h ambulatory blood pressure was significantly reduced (p < 0.001) from 148.8 +/- 17 to 137.2 +/- 15 mmHg (phase I) and to 133.4 +/- 13 mmHg (phase II). The mean diastolic 24-h ambulatory blood pressure was significantly decreased (p < 0.001) from 94.3 +/- 9 to 87.0 +/- 9 (phase I) and to 85.8 +/- 8 mmHg (phase II). The mean daytime and nighttime, systolic and diastolic 24-h ambulatory blood pressure were: wash-out--152.3 +/- 17, 140.2 +/- 21, 97.4 +/- 9, 86.8 +/- 13; phase I--139.9 +/- 15, 130.0 +/- 17, 89.3 +/- 9, 81.3 +/- 10; phase II--136.7 +/- 13, 125.3 +/- 15, 88.5 +/- 8, 79.1 +/- 10, respectively. Blood pressure load (percentage of systolic blood pressure values > 140 mmHg or of diastolic blood pressure values > 90 mmHg) was significantly reduced from 62.2/62 per cent (SBP/DBP), on the was-out, to 37.9/39.9 per cent (SBP/DBP) on phase I and to 32.3/34.3 per cent (SBP/DBP) on phase II; d) side effects: most frequently related were palpitations (2.3 per cent ), headache (1.1 per cent ), flush (1 per cent ) and ankle oedema (1 per cent ). They were in general, mild-to-moderate and disappeared after the first 3 weeks of treatment. Only two patients were withdrawn because of headache (one of them with previous diagnosis of migraine). CONCLUSION--I.SRO, given by oral route, in the dosage of 5 mg O.D. as monotherapy, was effective and well tolerated, promoted significant reduction on 24-h ambulatory blood pressure attenuating the early morning rise and did not interfere with the circadian rhythm of blood pressure. No significant differences were detected in the BP lowering effect when I.SRO was given during the morning or evening. These results may indicate that the drug is as suitable as one of the first choice for treating mild and moderate hypertensive patients
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Isradipine/administration & dosage , Hypertension/drug therapy , Blood Pressure Determination , Hypertension/physiopathology , Monitoring, Physiologic , Arterial PressureABSTRACT
Uma casuística total de 1.749 pacientes (87,8%) do sexo feminino, 12,5% do sexo masculino), com idade variando entre 50 e 80 anos, todos portadores de osteoporose, foram submetidos a tratamento medicamentoso intermitente com calcitonina de salmäo por via I. M. (1§ mês: 100Ul/dia na primeira semana e 50 Ul/dia na segunda semana de tratamento; 2§ ao 6§ mês: 50Ul/dia na 1ª e 2ª semanas de cada mês_) e cálcio efervecente por via oral na dose de 500 mg duas vezes ao dia continuamente por seis meses. Diversos parâmetros de ordem epidemiológica e clínica säo avaliados na amostra estudada. A casuística final do estudo foi de 1.192 pacientes e os resultados mostraram uma importante e significante melhora da dor óssea e das algias relacionadas à mobilidade referidas por estes pacientes. Os efeitos colaterais mais importantemente referidos foram náusea (8,8%) e calor na face e pescoço (6,7%). Näo se realizou durante este estudo método de quantificaçäo da massa óssea